Crk ELISA Kit for Mouse(Mus musculus) | EIAab.comCrk ELISA Kit for Mouse(Mus musculus)

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Crk (Gene name),

Adapter molecule crk (Protein name ), CRK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Crk(Crko);

Protein name:

Adapter molecule crk;

Alternative:

p38;Proto-oncogene c-Crk;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with ABL1, C3G, SOS, MAP4K1 and MAPK8 via its first SH3 domain. Interacts with BCAR1, CBL, CBLB, PXN, IRS4 and GAB1 via its SH2 domain upon stimulus-induced tyrosine phosphorylation. Interacts with several tyrosine-phosphorylated growth factor receptors such as EGFR, PDGFR and INSR via its SH2 domain. Interacts with DOCK1, DOCK4, C3G and EPS15 via its SH3 domain. Interacts with SHB (By similarity). Interacts with PEAK1 (By similarity). Interacts with DOCK3. Interacts with REPS1 and DDEF1/ASAP1 via its SH3 domain. Interacts with FASLG. Isoform Crk-II interacts with KIT. Interacts with EPHA3 (phosphorylated); mediates EFNA5-EPHA3 signaling through RHOA GTPase activation.

Function:

The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Cytoplasm Cell membrane Translocated to the plasma membrane upon cell adhesion.

Protein Attributes:

Sequence length:

304

Sequence:

50:

100:

150:

200:

250:

300:

304:

EDFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q64010

SMR:

Q64010

Pfam:

PF00017

UniGene:

Mm.280125

KEGG:

mmu:12928

Uniprot:

Q64010

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ELISA Kit for Mouse Adapter molecule crk

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E9658m

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96T

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ELISA Kit for Mouse Adapter molecule crk

Cat.:

E9658h

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96T

ELISA Kit for Mouse Adapter molecule crk

Cat.:

E9658r

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96T

ELISA Kit for Mouse Adapter molecule crk

Cat.:

E9658c

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96T

CLIA Kit for Mouse Adapter molecule crk

Cat.:

U9658c

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96T

CLIA Kit for Mouse Adapter molecule crk

Cat.:

U9658r

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96T

CLIA Kit for Mouse Adapter molecule crk

Cat.:

U9658h

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Packing:

96T

CLIA Kit for Mouse Adapter molecule crk

Cat.:

U9658m

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Packing:

96T

Polyclonal Antibody for Mouse Adapter molecule crk

Cat.:

P9658Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Adapter molecule crk

Cat.:

P9658Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Adapter molecule crk

Cat.:

P9658Rb-r

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Monoclonal Antibody for Mouse Adapter molecule crk

Protein for Mouse Adapter molecule crk

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat 3Y1 cells."
Ogawa S. , Toyoshima H. , Kozutsumi H. , Hagiwara K. , Sakai R. , Tanaka T. , Hirano N. , Mano H. , Yazaki Y. , Hirai H.
Oncogene9:1669-1678(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CRK-I AND CRK-II)
tissue: Liver.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRK-II)
strain: C57BL/6J.
tissue: Skin.
3.

"c-Abl kinase regulates the protein binding activity of c-Crk."
Feller S.M. , Knudsen B. , Hanafusa H.
EMBO J.13:2341-2351(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-221;INTERACTION WITH ABL1
4.

"An eps homology (EH) domain protein that binds to the ral-GTPase target, RalBP1."
Yamaguchi A. , Urano T. , Goi T. , Feig L.A.
J. Biol. Chem.272:31230-31234(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH REPS1
tissue: Muscle.
5.

"Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules."
Ito N. , Wernstedt C. , Engstrom U. , Claesson-Welsh L.
J. Biol. Chem.273:23410-23418(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT1
6.

"ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src."
Brown M.T. , Andrade J. , Radhakrishna H. , Donaldson J.G. , Cooper J.A. , Randazzo P.A.
Mol. Cell. Biol.18:7038-7051(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDEF1/ASAP1
7.

"Isolation and characterization of novel presenilin binding protein."
Kashiwa A. , Yoshida H. , Lee S. , Paladino T. , Liu Y. , Chen Q. , Dargusch R. , Schubert D. , Kimura H.
J. Neurochem.75:109-116(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK3
tissue: Brain.
8.

"Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling."
Lawrenson I.D. , Wimmer-Kleikamp S.H. , Lock P. , Schoenwaelder S.M. , Down M. , Boyd A.W. , Alewood P.F. , Lackmann M.
J. Cell Sci.115:1059-1072(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA3
9.

"Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk."
Lennartsson J. , Wernstedt C. , Engstrom U. , Hellman U. , Ronnstrand L.
Exp. Cell Res.288:110-118(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIT;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION
10.

"The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport."
Liu J. , DeYoung S.M. , Hwang J.B. , O'Leary E.E. , Saltiel A.R.
J. Biol. Chem.278:36754-36762(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBLB
11.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
13.

"Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk."
Wu X. , Knudsen B. , Feller S.M. , Zheng J. , Sali A. , Cowburn D. , Hanafusa H. , Kuriyan J.
Structure3:215-226(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 134-190
14.

"Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors."
Nguyen J.T. , Turck C.W. , Cohen F.E. , Zuckermann R.N. , Lim W.A.
Science282:2088-2092(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 133-191

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